In cases of anemia, the most common symptoms are weakness, shortness of breath, dizziness, and headaches.
The signs and symptoms of anisopoikilocytosis vary depending on the underlying cause.
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Join millions of students and clinicians who learn by Osmosis! Start Your Free Trial What are the signs and symptoms of anisopoikilocytosis? Chronic alcoholism can also affect the formation of blood cells and result in anisopoikilocytosis. Anisopoikilocytosis can also be a complication of chronic liver or kidney disease.Īdditionally, nutritional deficiencies that are associated with malnutrition, like folate and B12 deficiencies, may lead to anisopoikilocytosis. These irregular flows can consequently affect the shape and size of RBCs. For example, cardiac valvular diseases damage heart valves, which may then produce irregular flows of circulating blood. This causes most of the RBCs to lose their flexibility and take the shape of a first-quarter, sickle moon.Īside from anemias, several chronic disorders can result in anisopoikilocytosis. Lastly, sickle cell anemia is an inherited condition affecting the formation of hemoglobin. Megaloblastic anemia can morphologically change the RBCs into elliptocytes and dacrocytes. Meanwhile, hemolytic anemia features small RBCs that lack the central pallor (i.e., spherocytes) and fragments of RBCs with irregular shapes and sizes (i.e., schistocytes). Iron deficiency anemia, caused by a lack of iron, is characterized by the presence of RBCs that may be elongated and oval shaped (i.e., elliptocytes), as well as dacrocytes and target cells. Types of anemia that can cause anisopoikilocytosis include iron deficiency, hemolytic, megaloblastic, and sickle cell anemias. Thalassemia generally results in severe anisopoikilocytosis, with RBCs that resemble teardrops (i.e., dacrocytes) and have a concentration of hemoglobin in their center and periphery (i.e., target cells, also known as codocytes). Thalassemia is an inherited condition, in which production of hemoglobin, the protein in RBCs responsible for carrying oxygen to tissues, is impaired or reduced. The most common causes of anisopoikilocytosis are blood disorders, like thalassemia and types of anemia, as well as other chronic disorders and nutritional deficiencies.
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